Thaum muaj kev sib kis, cov kws kho mob tau siv cov tshuaj tiv thaiv kab mob monoclonal (laboratory-produced antibodies) los pab cov neeg mob tiv thaiv tus kab mob COVID-19. Tam sim no UC Davis cov kws tshawb fawb tab tom sim tsim cov tshuaj tiv thaiv kab mob monoclonal uas tuaj yeem pab tua cov mob ntev. Lub hom phiaj yog los tsim cov tshuaj tua kab mob txhua hli uas tuaj yeem hloov cov tshuaj opioids.
Txoj haujlwm no yog coj los ntawm Vladimir Yarov-Yarovoi thiab James Trimmer, cov xibfwb hauv Department of Physiology thiab Biology ntawm Membrane ntawm University of California, Davis Tsev Kawm Ntawv Tshuaj. Lawv tau sib sau ua ke pab pawg neeg sib koom ua ke uas suav nrog ntau tus kws tshawb fawb tib yam uas tau sim tig tarantula venom rau hauv cov tshuaj tua kab mob.
Ua ntej xyoo no, Yarov-yarovoy thiab trimmer tau txais kev pab txhawb kev noj qab haus huv ntawm National
Vim yog mob ntev, tib neeg tuaj yeem ua rau cov tshuaj opioids. Lub Tsev Haujlwm Saib Xyuas Kabmob Hauv Lub Tebchaws Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv tau kwv yees tias yuav muaj 107,622 tus neeg siv tshuaj ntau dhau kev tuag hauv Tebchaws Meskas xyoo 2021, ze li 15% ntau dua li kwv yees li 93,655 tus neeg tuag xyoo 2020.
"Txoj kev tsis ntev los no hauv cov txheej txheem thiab kev ua lej biology - kev siv cov khoos phis tawj kom nkag siab thiab ua qauv lom neeg - tau tsim lub hauv paus rau kev siv cov txheej txheem tshiab los tsim cov tshuaj tiv thaiv ua cov tshuaj zoo tshaj plaws rau kev kho mob ntev," Yarov hais. Yarovoy, tus neeg ua yeeb yam tseem ceeb ntawm Sai khoom plig.
"Monoclonal antibodies yog thaj chaw loj hlob sai tshaj plaws ntawm kev lag luam kws tshuaj thiab muaj ntau yam zoo dua cov tshuaj me me me me," Trimmer hais. Cov tshuaj me me yog cov tshuaj uas yooj yim nkag mus rau cov hlwb. Lawv tau siv dav hauv tshuaj.
Tau ntau xyoo, Trimmer's lab tau tsim ntau txhiab tus kab mob monoclonal sib txawv rau ntau lub hom phiaj, tab sis qhov no yog thawj zaug los tsim cov tshuaj tiv thaiv kab mob tsim los txo qhov mob.
Txawm hais tias nws zoo li futuristic, US Food and Drug Administration tau pom zoo cov tshuaj tiv thaiv kab mob monoclonal rau kev kho mob thiab tiv thaiv migraine. Cov tshuaj tshiab ua rau cov protein txuam nrog migraine hu ua calcitonin gene-related peptide.
Txoj haujlwm UC Davis muaj lub hom phiaj sib txawv - cov ion tshwj xeeb hauv cov paj hlwb hu ua voltage-gated sodium channels. Cov channel no zoo li "pores" ntawm cov paj hlwb.
“Cov paj hlwb muaj lub luag haujlwm rau kev xa cov cim mob hauv lub cev. Muaj peev xwm-gated sodium ion channels hauv paj hlwb yog qhov tseem ceeb ntawm qhov mob, "hais txog Yarov-Yarovoy. "Peb lub hom phiaj yog los tsim cov tshuaj tiv thaiv kab mob uas khi rau cov chaw sib kis tshwj xeeb ntawm qib molecular, inhibit lawv cov haujlwm thiab thaiv kev sib kis ntawm cov cim mob."
Cov kws tshawb fawb tau tsom mus rau peb qhov tshwj xeeb sodium channel cuam tshuam nrog kev mob: NaV1.7, NaV1.8, thiab NaV1.9.
Lawv lub hom phiaj yog los tsim cov tshuaj tiv thaiv uas phim cov channel no, zoo li tus yuam sij uas qhib lub xauv. Lub hom phiaj no yog tsim los thaiv kev sib kis ntawm cov teeb liab mob los ntawm cov channel yam tsis muaj kev cuam tshuam nrog lwm cov teeb liab kis los ntawm cov paj hlwb.
Qhov teeb meem yog tias cov qauv ntawm peb txoj kab uas lawv tab tom sim thaiv yog qhov nyuaj heev.
Txhawm rau daws qhov teeb meem no, lawv tig mus rau Rosetta thiab AlphaFold cov kev pab cuam. Nrog Rosetta, cov kws tshawb fawb tab tom tsim cov qauv tsim cov protein ntau thiab tshuaj xyuas cov qauv twg zoo tshaj plaws rau NaV1.7, NaV1.8, thiab NaV1.9 neural channels. Nrog AlphaFold, cov kws tshawb fawb tuaj yeem kuaj cov proteins uas tsim los ntawm Rosetta.
Thaum lawv txheeb xyuas qee qhov kev cog lus muaj protein ntau, lawv tsim cov tshuaj tiv thaiv kab mob uas tuaj yeem kuaj tau ntawm cov ntaub so ntswg neural tsim hauv chav kuaj. Tib neeg kev sim siab yuav siv sijhawm ntau xyoo.
Tab sis cov kws tshawb fawb tau zoo siab txog lub peev xwm ntawm txoj hauv kev tshiab no. Tsis yog-steroidal anti-inflammatory tshuaj (NSAIDs), xws li ibuprofen thiab acetaminophen, yuav tsum tau noj ob peb zaug ib hnub twg los txo qhov mob. Cov tshuaj tua kab mob Opioid feem ntau yog noj txhua hnub thiab muaj kev pheej hmoo ntawm kev quav tshuaj.
Txawm li cas los xij, cov tshuaj tiv thaiv kab mob monoclonal tuaj yeem ncig hauv cov ntshav rau ntau tshaj ib hlis ua ntej lawv thiaj li tawg los ntawm lub cev. Cov kws tshawb fawb xav tias cov neeg mob yuav tsum tswj hwm tus kheej cov tshuaj analgesic monoclonal antibody ib hlis ib zaug.
"Rau cov neeg mob uas mob ntev, qhov no yog qhov koj xav tau," Yarov-Yarovoy hais. “Lawv ntsib kev mob tsis yog rau hnub, tab sis rau lub lis piam thiab hli. Nws cia siab tias cov tshuaj tiv thaiv kab mob yuav tuaj yeem muab kev kho mob uas kav ntev li ob peb lub lis piam. "
Lwm pab pawg neeg suav nrog EPFL's Bruno Correia, Yale's Steven Waxman, EicOsis' William Schmidt thiab Heike Wolf, Bruce Hammock, Teanne Griffith, Karen Wagner, John T. Sack, David J. Copenhaver, Scott Fishman, Daniel J. Tancredi, Hai Nguyen, Phuong Tran Nguyen, Diego Lopez Mateos, thiab Robert Stewart ntawm UC Davis.
Out of business hours, holidays and weekends: hs-publicaffairs@ucdavis.edu916-734-2011 (ask a public relations officer)
Post lub sij hawm: Sep-29-2022